Fifteen-year-old twins, Sophie and Josh, find themselves caught up in the deadly struggle between rival alchemists, Nicholas Flamel and John Dee, over the possession of an ancient book that holds the secret formulas for alchemy and everlasting life.
While armies of the Shadowrealms gather and Machiavelli goes to Alcatraz to kill Perenelle Flamel, fifteen-year-old twins Sophie and Josh Newman accompany the Alchemist to England to seek Gilgamesh.